Nat Rev Rheumatol. 2009 Jul;5(7):392-9 Authors: Djouad F, Bouffi C, Ghannam S, Noël D, Jorgensen C Mesenchymal stem cells (MSCs), or multipotent mesenchymal stromal cells as they are also known, have been identified in bone marrow as well as in other tissues of the joint, including adipose, synovium, periosteum, perichondrium, and cartilage. These cells are…

Mod Rheumatol. 2009;19(5):522-9 Authors: Terabe F, Kitano M, Kawai M, Kuwahara Y, Hirano T, Arimitsu J, Hagihara K, Shima Y, Narazaki M, Tanaka T, Kawase I, Sano H, Ogata A Overgrowth of the synovium plays an important role in the pathogenesis of rheumatoid arthritis (RA). Platelet-derived growth factor (PDGF) is one of the most potent…

Arthritis Rheum. 2009 Aug;60(8):2284-93 Authors: Muhammad K, Roll P, Einsele H, Dörner T, Tony HP OBJECTIVE: Transient B cell depletion by rituximab has been used with clinical efficacy in the treatment of patients with rheumatoid arthritis (RA). Previous studies of B cell repopulation have shown long-term numerical reduction in memory B cells. Non-class-switched IgD+CD27+ memory…

Clin Lab. 2009;55(5-6):235-41 Authors: Marković M, Majkić-Singh N, Ignjatović S Patients with rheumatoid arthritis often conduct bathing in hot mineral water with a high concentrations of sulfate compounds in the water and ambient air. We investigated the effect of hyperthermia and sulfur as possible stress factors at transcriptional level in several proinflammatory genes in fibroblast…

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009 Jul;25(7):606-8, 611 Authors: Mao XD, Sun SJ, Pei ZY, Zhang LH AIM: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF). METHODS: RASF were pretreated with TP…

Arthritis Res Ther. 2009;11(5):R138 Authors: Thwin MM, Douni E, Arjunan P, Kollias G, Kumar PV, Gopalakrishnakone P INTRODUCTION: Secretory phospholipase A2 (sPLA2) and matrix metalloproteinase (MMP) inhibitors are potent modulators of inflammation with therapeutic potential, but have limited efficacy in rheumatoid arthritis (RA). The objective of this study was to understand the inhibitory mechanism of…

Arch Dis Child Educ Pract Ed. 2009 Oct;94(5):144-50 Authors: Beresford MW, Baildam EM Juvenile idiopathic arthritis (JIA) is the most common paediatric rheumatic disease with significant long-term morbidity and mortality. Major advances have taken place in recent years in our understanding and the evidence base of JIA. Key to this has been the serious collaborative…

Haematologica. 2010 Feb;95(2):284-92 Authors: Farge D, Labopin M, Tyndall A, Fassas A, Mancardi GL, Van Laar J, Ouyang J, Kozak T, Moore J, Kötter I, Chesnel V, Marmont A, Gratwohl A, Saccardi R BACKGROUND: Autologous hematopoietic stem cell transplantation has been used since 1996 for the treatment of severe autoimmune diseases refractory to approved therapies.…

Arthritis Rheum. 2009 Oct;60(10):2926-34 Authors: del Rey MJ, Izquierdo E, Caja S, Usategui A, Santiago B, Galindo M, Pablos JL OBJECTIVE: Hyperplasia and phenotypic changes in fibroblasts are often observed in chronic inflammatory lesions, and yet the autonomous pathogenic contribution of these changes is uncertain. The purpose of this study was to analyze the intrinsic…

J Rheumatol. 2009 Nov;36(11):2397-402 Authors: Kawashiri SY, Kawakami A, Iwamoto N, Fujikawa K, Aramaki T, Tamai M, Arima K, Kamachi M, Yamasaki S, Nakamura H, Tsurumoto T, Kono M, Shindo H, Ida H, Origuchi T, Eguchi K OBJECTIVE: Chemokine ligand 20 (CCL20) is a selective ligand for chemokine receptor 6 (CCR6). We investigated, both in…