Autoimmunity. 2008 Dec;41(8):632-8 Authors: Wulffraat NM, van Rooijen EM, Tewarie R, Brinkman D, Prakken B, Kuis W The majority of children with Juvenile Idiopathic Arthritis can nowadays be treated adequately. However despite the use of combinations of antirheumatic drugs, corticosteroids and the newer so called biologicals (blocking the TNF, Interleukin 1 or Interleukin 6 pathways)…

Curr Stem Cell Res Ther. 2009 Jan;4(1):61-9 Authors: Kastrinaki MC, Papadaki HA Mesenchymal stromal cells (MSC) isolated from a variety of adult tissues including the bone marrow (BM), have the capacity to differentiate into different cell types such as bone and cartilage and have therefore attracted scientific interest as potential therapeutic tools for tissue repair.…

Mol Immunol. 2009 Nov;47(1):46-51 Authors: Abinun M, Flood TJ, Cant AJ, Veys P, Gennery AR, Foster HE, Friswell M, Baildam E, Davidson J, Southwood TR, Livermore P, Wedderburn LR As part of collaborative multi-centre study started in 2000, 7 children in the UK fulfilled the inclusion criteria for treatment with autologous T cell depleted (TCD)…

Arthritis Res Ther. 2009;11(1):211 Authors: Ringe J, Sittinger M Diseases such as degenerative or rheumatoid arthritis are accompanied by joint destruction. Clinically applied tissue engineering technologies like autologous chondrocyte implantation, matrix-assisted chondrocyte implantation, or in situ recruitment of bone marrow mesenchymal stem cells target the treatment of traumatic defects or of early osteoarthritis. Inflammatory conditions…

Scand J Rheumatol. 2009;38(4):235-9 Authors: Blaschke S, Viereck V, Schwarz G, Klinger HM, Guerluek S, Müller GA OBJECTIVE: Statins, such as atorvastatin (ATV), are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors known to exert lipid-lowering but also anti-inflammatory, effects. In this study, we analysed the in vitro effects of ATV on peripheral blood mononuclear cells (PBMCs)…

Zhongguo Zhong Yao Za Zhi. 2008 Dec;33(23):2838-41 Authors: Xie XF, Li J, Chen Z, Hu CM, Chen WW OBJECTIVE: To investigate the effect on the extract of total flavonoids of Chrysanthemum indicum (TFC) on adjuvant arthritis synovial cells. METHOD: SD rats were divided randomly into six groups including normal, model, TFC (84, 168, 336 mg…

Blood. 2009 May 14;113(20):4834-40 Authors: Carson KR, Evens AM, Richey EA, Habermann TM, Focosi D, Seymour JF, Laubach J, Bawn SD, Gordon LI, Winter JN, Furman RR, Vose JM, Zelenetz AD, Mamtani R, Raisch DW, Dorshimer GW, Rosen ST, Muro K, Gottardi-Littell NR, Talley RL, Sartor O, Green D, Major EO, Bennett CL Rituximab improves…

Arthritis Res Ther. 2009;11(2):R49 Authors: Bang JS, Oh da H, Choi HM, Sur BJ, Lim SJ, Kim JY, Yang HI, Yoo MC, Hahm DH, Kim KS INTRODUCTION: The objective of this study was to determine the anti-inflammatory, nociceptive, and antiarthritic effects of piperine, the active phenolic component in black pepper extract. METHODS: The in vitro…

Arthritis Rheum. 2009 Apr;60(4):1006-19 Authors: González MA, Gonzalez-Rey E, Rico L, Büscher D, Delgado M OBJECTIVE: Rheumatoid arthritis (RA) is a chronic autoimmune disease caused by loss of immunologic self tolerance and characterized by chronic joint inflammation. Adult mesenchymal stem cells (MSCs) were recently found to suppress effector T cell responses and to have beneficial…

Methods Mol Biol. 2009;512:233-48 Authors: Thomson S, Udalova IA Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised by pain, swelling and progressive destruction of synovial joints. The synovial membranes of the affected joints markedly increase in size due to infiltration of several cell types, of which macrophages, lymphocytes and fibroblasts are most abundant. These…