• After the Covid pandemic, we have resumed stem cell treatments. Appropriate sterility and great care in sanitisation is undertaken as usual. If you are unwell with a cough cold or respiratory symptoms it is best to postpone your procedure.

Rheumatoid Arthritis Library

Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor.

150 150 NZ Stem Cell Treatment Centre

Biochem Pharmacol. 2010 May 15;79(10):1445-54 Authors: Mbalaviele G, Pauley AM, Shaffer AF, Zweifel BS, Mathialagan S, Mnich SJ, Nemirovskiy OV, Carter J, Gierse JK, Wang JL, Vazquez ML, Moore WM, Masferrer JL Inflammation-induced microsomal prostaglandin E synthase-1 (mPGES-1) is the terminal enzyme that synthesizes prostaglandin E(2) (PGE(2)) downstream of cyclooxygenase-2 (COX-2). The efficacy of nonsteroidal…

read more

Lipoteichoic acid enhances IL-6 production in human synovial fibroblasts via TLR2 receptor, PKCdelta and c-Src dependent pathways.

150 150 NZ Stem Cell Treatment Centre

Biochem Pharmacol. 2010 Jun 1;79(11):1648-57 Authors: Tang CH, Hsu CJ, Yang WH, Fong YC Patients with rheumatoid arthritis (RA) are at increased risk of developing infections and appear to be particularly susceptible to septic arthritis. Lipoteichoic acid (LTA), a cell wall component of Gram-positive bacteria is an amphiphilic, negatively charged glycolipid. However, the effects of…

read more

Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors.

150 150 NZ Stem Cell Treatment Centre

Arthritis Rheum. 2010 Mar;62(3):683-93 Authors: Sacre S, Medghalchi M, Gregory B, Brennan F, Williams R OBJECTIVE: Selective serotonin reuptake inhibitors (SSRIs), in addition to their antidepressant effects, have been reported to have antiinflammatory effects. The aim of this study was to assess the antiarthritic potential of 2 SSRIs, fluoxetine and citalopram, in murine collagen-induced arthritis…

read more

Autologous stem cell transplantation in autoimmune and rheumatic diseases: from the molecular background to clinical applications.

150 150 NZ Stem Cell Treatment Centre

Scand J Rheumatol. 2010;39(1):1-11 Authors: Szodoray P, Varoczy L, Szegedi G, Zeher M Autoimmune diseases have a multifactorial origin. Because of disturbances of the immune system, autoreactive T and B cells target self-antigens, leading to permanent organ damage. Despite novel therapeutic protocols, the disease course is chronic and in many instances the outcome is lethal.…

read more

Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis.

150 150 NZ Stem Cell Treatment Centre

Immunol Rev. 2010 Jan;233(1):233-55 Authors: Bartok B, Firestein GS Rheumatoid arthritis (RA) remains a significant unmet medical need despite significant therapeutic advances. The pathogenesis of RA is complex and includes many cell types, including T cells, B cells, and macrophages. Fibroblast-like synoviocytes (FLS) in the synovial intimal lining also play a key role by producing…

read more

Interferon-gamma inhibits interleukin-1beta-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis.

150 150 NZ Stem Cell Treatment Centre

Arthritis Res Ther. 2010;12(2):R49 Authors: Page CE, Smale S, Carty SM, Amos N, Lauder SN, Goodfellow RM, Richards PJ, Jones SA, Topley N, Williams AS INTRODUCTION: The first few months after symptom onset represents a pathologically distinct phase in rheumatoid arthritis (RA). We used relevant experimental models to define the pathological role of interferon-gamma (IFN-gamma)…

read more

Modulation of the response of rheumatoid arthritis synovial fibroblasts to proinflammatory stimulants with cyclic tensile strain.

150 150 NZ Stem Cell Treatment Centre

Cytokine. 2010 Jul;51(1):35-41 Authors: Bader RA, Wagoner KL Although physical therapy has been shown to be an effective method for treatment of rheumatoid arthritis, a thorough investigation on the impact of mechanical signals upon the complex cytokine network associated with pathogenesis has not yet been conducted. In the current study, our research group investigated the…

read more

Autotaxin and lysophospholipids in rheumatoid arthritis.

150 150 NZ Stem Cell Treatment Centre

Curr Opin Investig Drugs. 2010 May;11(5):515-26 Authors: Bourgoin SG, Zhao C Autotaxin (ATX) is an autocrine motility-stimulating factor and an extracellular enzyme that catalyzes the hydrolysis of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA). Although ATX can also hydrolyze sphingosylphosphorylcholine (SPC) to sphingosine-1-phosphate (S1P), the major source of extracellular S1P originates from the intracellular phosphorylation of…

read more

Salivary gland stem cells: Can they restore radiation-induced salivary gland dysfunction?]

150 150 NZ Stem Cell Treatment Centre

HNO. 2010 Jun;58(6):556-63 Authors: Rotter N, Schwarz S, Jakob M, Brandau S, Wollenberg B, Lang S Adult stem cells are actively investigated in the fields of regenerative medicine and tissue engineering, as they exhibit specific characteristics that make them promising candidates for cellular therapies. Depending on their tissue of origin these characteristics include long-term proliferation…

read more

Therapeutic potential of adult bone marrow-derived mesenchymal stem cells in diseases of the skeleton.

150 150 NZ Stem Cell Treatment Centre

J Cell Biochem. 2010 Oct 1;111(2):249-57 Authors: Chanda D, Kumar S, Ponnazhagan S Mesenchymal stem cells (MSCs) are the most popular among the adult stem cells in tissue engineering and regenerative medicine. Since their discovery and functional characterization in the late 1960s and early 1970s, MSCs or MSC-like cells have been obtained from various mesodermal…

read more