Z Rheumatol. 2008 Dec;67(8):684-8 Authors: Albrecht I, Niesner U, Janke M, Radbruch A, Chang H State-of-the-art immunosuppressive therapies, though efficient in the treatment of rheumatic inflammatory disorders, in most cases do not provide a cure. Complete immunablation and the associated deletion of the reactive immunological memory followed by reconstitution of the “healthy” immune system from…

Z Rheumatol. 2008 Dec;67(8):640-5 Authors: Sprott H Joint pain is one of the most common forms of pain and is experienced by almost a third of the population at some time. To date, it has not been possible to treat joint pain effectively and side effects of commonly prescribed drugs are often hazardous. Therefore, improvements…

Z Rheumatol. 2008 Dec;67(8):716-22 Authors: Kötter I, Schmalzing M, Henes J, Vogel W, Kanz L Transplantations of autologous or allogeneic stem cells from bone marrow or peripheral blood are preformed for the treatment of resistant autoimmune diseases. Data have been systematically collected since 1996. We describe the historical development of this procedure for autoimmune diseases,…

Pharm Res. 2009 Feb;26(2):263-75 Authors: Yao Y, Wang C, Varshney RR, Wang DA The use of antisense strategies such as ribozymes, oligodeoxynucleotides (ODNs) and small interfering RNA (siRNA) in gene therapy, in conjunction with the use of stem cells and tissue engineering, has opened up possibilities in curing degenerative diseases and injuries to non-regenerating organs…

Arthritis Rheum. 2008 Dec;58(12):3765-75 Authors: Rice JW, Veal JM, Fadden RP, Barabasz AF, Partridge JM, Barta TE, Dubois LG, Huang KH, Mabbett SR, Silinski MA, Steed PM, Hall SE OBJECTIVE: To evaluate the ability of SNX-7081, a novel small molecule inhibitor of Hsp90, to block components of inflammation, including cytokine production, protein kinase activity, and…

J Rheumatol. 2009 Jan;36(1):141-55 Authors: Sun Y, Mauerhan DR, Firestein GS, Loeffler BJ, Hanley EN, Gruber HE OBJECTIVE: To examine the differential gene expression in telomerase transduced osteoarthritis fibroblast-like synoviocytes (hTERT-OA 13A FLS) and telomerase transduced rheumatoid arthritis FLS (hTERT-RA 516 FLS) and test the hypothesis that longterm culture of hTERT-OA 13A FLS display a…

Tissue Eng Part A. 2009 Jul;15(7):1579-89 Authors: Lombardo E, DelaRosa O, Mancheño-Corvo P, Menta R, Ramìrez C, Büscher D Human adipose-derived stem cells (hASCs) are mesenchymal stem cells with reduced immunogenicity and the capability to modulate immune responses. These properties make hASCs of special interest as therapeutic agents in the settings of chronic inflammatory and…

Actas Dermosifiliogr. 2008 Dec;99(10):803-7 Authors: del Pozo J, Garcìa-Silva J, Yebra-Pimentel MT Graft-vs-host disease is still the leading cause of morbidity and mortality in patients undergoing bone marrow transplantation. It is important to start treatment early to reduce the severity and consequences of this complication. Cutaneous lesions are often the presenting compliant of graft-vs-host disease…

Dermatol Online J. 2008;14(11):17 Authors: Toyozawa S, Yamamoto Y, Nishide T, Kishioka A, Kanazawa N, Matsumoto Y, Kuroyanagi Y, Furukawa F Pyoderma gangrenosum (PG) is an idiopathic, inflammatory, ulcerative disease of undetermined cause. Both topical and systemic treatments of corticosteroids and cyclosporine are commonly used for the ulcers of PG, but these ulcers are often…

Int Immunopharmacol. 2009 Mar;9(3):268-76 Authors: Lee JD, Huh JE, Jeon G, Yang HR, Woo HS, Choi DY, Park DS Rheumatoid arthritis (RA) is an aggressive inflammatory disease in which cytokines/chemokines are thought to recruit leukocytes and induce angiogenesis. The aim of this study is to investigate the effect of flavonol-rich residual layer of hexane fraction…