BJU Int. 2009 Jul;104(2):257-62 Transdifferentiation of rat fetal brain stem cells into penile smooth muscle cells. Song Y, Mehta N, Sheh B, Saljooque F, U HS, Rajasekaran M. Abstract OBJECTIVES: To evaluate whether rat fetal brain stem cells can be induced to acquire cell fates outside the nervous system, hypothesising that cell-based replacement therapy with…

6(4):967-79 Fibroblast growth factor 2 promotes endothelial differentiation of adipose tissue-derived stem cells. Ning H, Liu G, Lin G, Yang R, Lue TF, Lin CS. Abstract INTRODUCTION: Adipose tissue-derived stem cells (ADSC) could potentially restore endothelial function in vasculogenic erectile dysfunction (ED). The mechanism for ADSC endothelial differentiation remained unidentified. AIM: To test whether ADSC…

2009 Mar-Apr;(2):46-51 Modern aspects of pathophysiology and prevention of erectile dysfunction and cavernous fibrosis after radical prostatectomy. Veliev EI, Vanin AF, Kotov SV, Shiahlo VK. Abstract Partial denervation of cavernous tissue (CT) during nerve sparing radical prostatectomy (RPE) can cause development of neuropraxy and cavernous fibrosis (CF) resulting in erectile dysfunction (ED) after operation. We…

6 Suppl 3:320-7 Potential of adipose-derived stem cells for treatment of erectile dysfunction. Lin G, Banie L, Ning H, Bella AJ, Lin CS, Lue TF. Abstract Adipose-derived stem cells (ADSCs) are a somatic stem cell population contained in fat tissue that possess the ability for self-renewal, differentiation into one or more phenotypes, and functional regeneration…

8(10):1521-38 A review of current progress in gene and stem cell therapy for erectile dysfunction. Gur S, Kadowitz PJ, Hellstrom WJ: Abstract BACKGROUND: Current gene-based strategies for treatment of erectile dysfunction (ED) are based on the nitric oxide (NO)/cGMP system; although growth factors, calcium sensitization, and potassium channel expression have been studied. Initial investigations of…

102(2):220-4; discussion 224. Epub 2008 Jul 1. Human neural crest stem cells transplanted in rat penile corpus cavernosum to repair erectile dysfunction. Song YS, Lee HJ, Park IH, Lim IS, Ku JH, Kim SU OBJECTIVE: To investigate the feasibility of applying neural crest stem cells (NCSCs), with multipotent capacity, to repair injury in the penile…

Stem and endothelial progenitor cells in erection biology. Strong TD, Gebska MA, Champion HC, Burnett AL, Bivalacqua TJ. Erectile dysfunction (ED) is defined as the consistent inability to obtain or maintain an erection forsatisfactory sexual relations. The past 20 years of basic science research on erection physiology has been devoted to investigating the pathogenesis of…

Gonzalez-Cadavid NF: Effect of muscle-derived stem cells on the restoration of corpora cavernosansmooth muscle and erectile function in the aged rat. Nolazco G, Kovanecz I, Vernet D, Gelfand RA, Tsao J, Ferrini MG, Magee T, Rajfer J, OBJECTIVE: To determine whether skeletal muscle-derived stem cells (MDSCs) convert into smooth muscle cells (SMCs) both in vitro…

Recent advances in andrology-related stem cell research. Lin CS, Xin ZC, Deng CH, Ning H, Lin G, Lue TF Abstract Stem cells hold great promise for regenerative medicine because of their ability to self-renew and to differentiate into various cell types. Although embryonic stem cells (BSC) have greater differentiation potential than adult stem cells, the…

Endothelium-specific gene and stem cell-based therapy for erectile dysfunction. Strong TD, Gebska MA, Burnett AL, Champion HC, Bivalacqua TJ. Abstract Erectile dysfunction (ED) commonly results from endothelial dysfunction of the systemic vasculature. Although phosphodiesterase type 5 (PDE-5) inhibitors are effective at treating most cases of ED, they must be taken routinely and are ineffectual for…