Recent advances in andrology-related stem cell research. Lin CS, Xin ZC, Deng CH, Ning H, Lin G, Lue TF Abstract Stem cells hold great promise for regenerative medicine because of their ability to self-renew and to differentiate into various cell types. Although embryonic stem cells (BSC) have greater differentiation potential than adult stem cells, the…

Endothelium-specific gene and stem cell-based therapy for erectile dysfunction. Strong TD, Gebska MA, Burnett AL, Champion HC, Bivalacqua TJ. Abstract Erectile dysfunction (ED) commonly results from endothelial dysfunction of the systemic vasculature. Although phosphodiesterase type 5 (PDE-5) inhibitors are effective at treating most cases of ED, they must be taken routinely and are ineffectual for…

10(1):54-9 Emerging neuromodulatory molecules for the treatment of neurogenic erectile dysfunction caused by cavernous nerve injury. Bella AJ, Lin G, Cagiannos I, Lue TF. Abstract Advances in the neurobiology of growth factors, neural development, and prevention of cell death have resulted in a heightened clinical interest for the development of protective and regenerative neuromodulatory strategies…

594868 Preclinical evidence for the benefits of penile rehabilitation therapy following nerve-sparing radicalbprostatectomy. Albersen M, Joniau S, Claes H, Van Poppel H Abstract Erectile dysfunction following radical prostatectomy remains a frequent problem despite the development of nerve-sparing techniques. This erectile dysfunction is believed to be neurogenic, enhanced by hypoxia-induced structural changes which result in additional…

52(6):1580-9 Tissue engineering for the lower urinary tract: a review of a state of the art approach. Sievert KD, Amend B, Stenzl A Abstract OBJECTIVES: Tissue engineering (TE) has become synonymous with physiological and functional reconstructive approaches in medicine. Although the goals of TE are ambitious and have not yet been attained, significant milestones have…

19(4):378-85. Epub 2007 Apr 26. Potential differentiation of human mesenchymal stem cell transplanted in rat corpus cavernosumn toward endothelial or smooth muscle cells. Song YS, Lee HJ, Park IH, Kim WK, Ku JH, Kim SU. Abstract One of the causes of erectile dysfunction (ED) is the damaged penile cavernous smooth muscle cells (SMCs) and sinus…

9(3):361-7. Magnetic resonance evaluation of human mesenchymal stem cells in corpus cavernosa of rats and rabbits. Song YS, Ku JH, Song ES, Kim JH, Jeon JS, Lee KH, Kim SJ, Cheong HJ, Lim IS, Choi D, Won JH Abstract AIM: To investigate whether the biological process of superparamagnetic iron oxide (SPIO)-labeled human mesenchymal stem cells…

51(5):1411-7; discussion 1417-9 Relationship between vascular damage degrees and endothelial progenitor cells in patients with erectile dysfunction: effect of vardenafil administration and PDE5 expression in the bone marrow. Foresta C, Caretta N, Lana A, De Toni L, Biagioli A, Vinanzi C, Ferlin A: Abstract OBJECTIVES: To evaluate the levels of circulating progenitor cells (PCs) and…

2007 Apr;7(2):131-53 Gene and stem cell therapy in the treatment of erectile dysfunction and pulmonary hypertension; potential treatments for the common problem of endothelial dysfunction. Nossaman BD, Gur S, Kadowitz PJ. Abstract The endothelium has an important regulatory role in the maintenance of vascular homeostasis, vascular tone, blood flow, and in preserving a non-thrombogenic blood-tissue…

2007 Mar;292(3):H1278-90. Epub 2006 Oct Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age-associated erectile dysfunction. Bivalacqua TJ, Deng W, Kendirci M, Usta MF, Robinson C, Taylor BK, Murthy SN, Champion HC, Hellstrom WJ, Kadowitz PJ. Abstract Mesenchymal stem cells (MSCs) can be used in adult stem cell-based…