• After the Covid pandemic, we have resumed stem cell treatments. Appropriate sterility and great care in sanitisation is undertaken as usual. If you are unwell with a cough cold or respiratory symptoms it is best to postpone your procedure.

Neurology Library

Human neural stem cells genetically modified to overexpress brain-derived neurotrophic factor promote functional recovery and neuroprotection in a mouse stroke model.

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J Neurosci Res. 2010 Nov 15;88(15):3282-94. Human neural stem cells genetically modified to overexpress brain-derived neurotrophic factor promote functional recovery and neuroprotection in a mouse stroke model. Lee HJ, Lim IJ, Lee MC, Kim SU. Source Medical Research Institute, Chung-Ang University College of Medicine, Seoul, Korea. Abstract Intracerebral hemorrhage (ICH) is a lethal stroke type;…

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Critical questions for preclinical trials on safety and efficacy of vascular endothelial growth factor-based therapeutic angiogenesis for ischemic stroke.

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CNS Neurol Disord Drug Targets. 2011 Mar;10(2):215-34. Critical questions for preclinical trials on safety and efficacy of vascular endothelial growth factor-based therapeutic angiogenesis for ischemic stroke. Manoonkitiwongsa PS. Source Neural Engineering Program, Huntington Medical Research Institutes, Pasadena, CA, USA. stevemanoon@hotmail.com Abstract Therapeutic angiogenesis is a novel treatment for ischemic stroke, and vascular endothelial growth factor…

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Progress and prospects: stem cells and neurological diseases.

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Gene Ther. 2011 Jan;18(1):1-6. Epub 2010 Sep 30. Progress and prospects: stem cells and neurological diseases. Gögel S, Gubernator M, Minger SL. Source Wolfson Centre for Age-Related Diseases, Guy’s Campus, King’s College London, London, UK. stefanie.gogel@kcl.ac.uk Abstract The central nervous system has limited capacity of regenerating lost tissue in slowly progressive, degenerative neurological conditions such…

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Vascular protection and restorative therapy in ischemic stroke.

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Cell Transplant. 2011;20(1):95-7. Epub 2010 Sep 30. Vascular protection and restorative therapy in ischemic stroke. Yamashita T, Deguchi K, Nagotani S, Abe K. Source Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. Abstract Possible strategies for treating stroke include: 1) thrombolytic therapy with tissue plasminogen activator (tPA): restoring…

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Neural induction with neurogenin1 increases the therapeutic effects of mesenchymal stem cells in the ischemic brain.

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Stem Cells. 2008 Sep;26(9):2217-28. Epub 2008 Jul 10. Neural induction with neurogenin1 increases the therapeutic effects of mesenchymal stem cells in the ischemic brain. Kim SS, Yoo SW, Park TS, Ahn SC, Jeong HS, Kim JW, Chang DY, Cho KG, Kim SU, Huh Y, Lee JE, Lee SY, Lee YD, Suh-Kim H. Source Department of…

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Treating muscular dystrophy & stem cells

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Neuromuscul Disord. 2011 Jan;21(1):4-12. Epub 2010 Nov 4. Stem cells to treat muscular dystrophies – where are we? Meng J, Muntoni F, Morgan JE. Source The Dubowitz Neuromuscular Centre, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, United Kingdom. Abstract The muscular dystrophies are inherited disorders characterised by progressive muscle wasting and…

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Parkinson’s disease and stem cells.

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2011 Jan; 1812(1) : 1-11. Epub 2010 Aug 14. Stem cell potential in Parkinson’s disease and molecular factors for the generation of dopamine neurons. Kim HJ. Abstract Parkinson’s disease (PD) involves the loss of dopamine (DA) neurons, making it the most expected neurodegenerative disease to be treated by cell replacement therapy. Stem cells are a…

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Implications for cell based therapies in Parkinson’s.

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Biol Blood Marrow Transplant. 2010 Nov; 16(11) : 1530-40. Epub 2010 Jun 10. Intranigral transplantation of epigenetically induced BDNF-secreting human mesenchymal stem cells: implications for cellbased therapies in Parkinson’s disease. Somoza R, Juri C, Baes M, Wyneken U, Rubio FJ. Institute of Science, Clinica Alemana Universidad del Desarrollo, Santiago, Chile. Abstract It is thought that…

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Ageing and neurodegenerative diseases.

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Ageing Res Rev. 2010 Nov; 9 Suppl 1 : S36-46. Epub 2010 Aug 21. Ageing and neurodegenerative diseases. Hung CW, Chen YC, Hsieh WL, Chiou SH, Kao CL. Department of Neurology, Zhongxiao Branch, Taipei City Hospital/No 87, Tongde Rd, Nangang Dist, Taipei City 115, Taiwan. Abstract Ageing, which all creatures must encounter, is a challenge…

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Delivery of neurotrophins to the Parkinsonian rat brain.

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Brain Res. 2010 Nov 4; 1359 : 33-43. Epub 2010 Aug 21. Potential of rat bone marrow-derived mesenchymal stem cells as vehicles for delivery of neurotrophins to the Parkinsonian rat brain. Moloney TC, Rooney GE, Barry FP, Howard L, Dowd E. The Department of Pharmacology & Therapeutics, National University of Ireland, Galway, Ireland; National Centre…

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