• After the Covid pandemic, we have resumed stem cell treatments. Appropriate sterility and great care in sanitisation is undertaken as usual. If you are unwell with a cough cold or respiratory symptoms it is best to postpone your procedure.

Autologous Stromal Vascular Fraction: A New Era of Personal Cell Therapy

150 150 NZ Stem Cell Treatment Centre

Journal of Stem Cells Research Development & Therapy, 2018, 4: 011

Autologous Stromal Vascular Fraction: A New Era of Personal Cell Therapy
Elliot B Lander and Mark H Berman
California Stem Cell Treatment Center, Cell Surgical Network Inc., California, USA

 

ABSTRACT

The fascinating story of Stromal Vascular Fraction (SVF) and its prominent role in autologous regenerative therapies (or Personal Cell Therapy – PCT) continues to evolve as scientific and regulatory issues develop. The primary objective of this special report will elucidate the history, composition and scientific analysis of SVF as an autologous biologic experiencing widespread clinical use. SVF has several distinct features that prevent it from ever being manufactured as a mass produced pharmaceutical and distributed for clinical use. Autologous SVF contains a unique mixture of 4 different types of autologous stem cells in an extremely rich cytokine milieu. It is intended to be used fresh and at point of care obviating its use in commercialization. It is personalized with the patient’s own DNA, and it contains the patient’s own biologic profile of possible measurable or unmeasurable communicable diseases. Other stem cell products being developed as drugs under research and development differ from autologous SVF as they generally contain doses of a single cell types that may or may not be autologous. Personal Cell Therapy using autologous biologic products should be protected from overbearing regulation with its use supported by clinical trials helping us to learn more about its regenerative potential. Laboratory investigations can then optimally help optimize areas that need further support.

CONCLUSION

Despite regulatory and financial hurdles, the medical and intellectual future of personal cell therapy using autologous SVF remains optimistic. We have seen positive outcomes using SVF at point of care in mitigating a number of medical problems and diseases. One of the limitations of autologous point of care SVF is that certain conditions such as advanced neurodegenerative disorders and autoimmune disorders seem to require repeat treatments or higher cell counts than cannot be realistically obtained at a point of care procedure using SVF. This opens up the door for cryobanking and expanding SVF cells. Only one lineage of mesenchymal stem cells is produced in these expanded cultures but very high numbers can be achieved conveniently and banked for future uses. Industrialized production of one’s own stem cells is potentially a powerful tool that could keep us living longer and better. In synergy with our in-vitro repair system, large numbers of banked cells can be exogenously deployed as a “surge” to mitigate many conditions associated with trauma, radiation, surgery, violence, infection, behavioral and lifestyle issues (e.g. tobacco abuse), work or play overutilization injuries, genetic and epigenetic conditions (both mental and physical), toxins, cancer, and even ageing. This hails the beginning of true personalized medical treatments.

To read the full article, click here DOI:10.24966/SRDT-2060/100011

Related: Autologous Stromal Vascular Fraction; Hematopoietic stem cells; Mesenchymal stem cells; Stem cell therapy; Stromal vascular fraction