• After the Covid pandemic, we have resumed stem cell treatments. Appropriate sterility and great care in sanitisation is undertaken as usual. If you are unwell with a cough cold or respiratory symptoms it is best to postpone your procedure.

Orthopedics Library

In vivo intervertebral disc regeneration using stem cell-derived chondroprogenitors.

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J Neurosurg Spine. 2009 Mar;10(3):265-72 Authors: Sheikh H, Zakharian K, De La Torre RP, Facek C, Vasquez A, Chaudhry GR, Svinarich D, Perez-Cruet MJ OBJECT: There is currently no biologic therapy to repair or restore a degenerated intervertebral disc. A potential solution may rest with embryonic stem cells (ESCs), which have a potential to grow…

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Olfactory stem cells can be induced to express chondrogenic phenotype in a rat intervertebral disc injury model.

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Spine J. 2009 Jul;9(7):585-94 Authors: Murrell W, Sanford E, Anderberg L, Cavanagh B, Mackay-Sim A BACKGROUND: In humans, lower back pain is one of the most common causes of morbidity. Many studies implicate degeneration of intervertebral discs as the cause. In the normal intervertebral disc, the nucleus pulposus exerts a hydrostatic pressure against the constraining…

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Human disk cells from degenerated disks and mesenchymal stem cells in co-culture result in increased matrix production.

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Cells Tissues Organs. 2010;191(1):2-11 Authors: Svanvik T, Henriksson HB, Karlsson C, Hagman M, Lindahl A, Brisby H Transplantation of mesenchymal stem cells (MSCs) has been suggested for disk degeneration, which is characterized by dysfunctional cells and low proteoglycan production. The aim of this study was to examine the effects of a 3D co-culture system using…

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Biologic solutions for degenerative disk disease.

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J Spinal Disord Tech. 2009 Jun;22(4):297-308 Authors: Fassett DR, Kurd MF, Vaccaro AR STUDY DESIGN: Literature review. OBJECTIVE: Review the potential use of biologic therapies for the treatment of degenerative disk disease. SUMMARY OF BACKGROUND DATA: Degeneration of the intervertebral disk is a common occurrence which, although asymptomatic in most instances, may result in axial…

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Cell-based regeneration of intervertebral disc defects: review and concepts.

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Int J Artif Organs. 2009 Apr;32(4):197-203 Authors: Freimark D, Czermak P During the last century low back pain has emerged as a widespread disease often caused by intervertebral disc degeneration (IDD). IDD is a complex problem in which a variety of causes play a role. As IDD causes high costs, corporate interest has led to…

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Mesenchymal stem cells arrest intervertebral disc degeneration through chondrocytic differentiation and stimulation of endogenous cells.

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Mol Ther. 2009 Nov;17(11):1959-66 Authors: Yang F, Leung VY, Luk KD, Chan D, Cheung KM Degenerative disc disease (DDD) is a common disease which affects millions of people. Autograft of the bone marrow derived mesenchymal stem cells (BMSCs) have been shown to have the ability to arrest degeneration in rabbit and canine intervertebral discs. In…

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Nucleus pulposus tissue engineering: a brief review.

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Eur Spine J. 2009 Nov;18(11):1564-72 Authors: Yang X, Li X Symptomatic intervertebral disc degeneration is associated with several spinal diseases, which cause losses of life quality and money. Tissue engineering provides a promising approach to recover the functionality of the degenerative intervertebral disc. Most studies are directed toward nucleus pulposus (NP) tissue engineering because disc…

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Intervertebral disc regeneration in an ex vivo culture system using mesenchymal stem cells and platelet-rich plasma.

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Biomaterials. 2009 Oct;30(29):5523-33 Authors: Chen WH, Liu HY, Lo WC, Wu SC, Chi CH, Chang HY, Hsiao SH, Wu CH, Chiu WT, Chen BJ, Deng WP An ex vivo degenerative intervertebral disc (IVD) organ culture system was established for the screening of disc regeneration agents. Its application was demonstrated by a stem cell and growth…

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Advances of nucleus pulposus cells for treating intervertebral disc degeneration

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Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009 Jul;23(7):864-7 Authors: Wang F, Wang Y, Wu X OBJECTIVE: To introduce the research of nucleus pulposus cells for treating intervertebral disc degeneration. METHODS: The original articles in recent years about nucleus pulposus cells for treating intervertebral disc degeneration were extensively reviewed, and retrospective and comprehensive…

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New perspectives on degenerative disease treatment

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Acta Reumatol Port. 2009 Apr-Jun;34(2B):327-35 Authors: da Silva MR, Domingues CJ, Pinto RP, Neves N, Matos RM, Tulha JM, Cabral AT The degenerative disc disease (DDD) is a chronic and multifactorial condition of the intervertebral disc that can manifest itself by axial pain, radiculopathy, myelopathy and spinal stenosis. It constitutes an increasing cause of lumbar…

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