• After the Covid pandemic, we have resumed stem cell treatments. Appropriate sterility and great care in sanitisation is undertaken as usual. If you are unwell with a cough cold or respiratory symptoms it is best to postpone your procedure.

Orthopedics Library

Biological treatment for degenerative disc disease: implications for the field of physical medicine and rehabilitation.

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Am J Phys Med Rehabil. 2008 Sep;87(9):694-702 Authors: Zhang Y, An HS, Tannoury C, Thonar EJ, Freedman MK, Anderson DG Spine care is a fast-growing sector of the outpatient practice for physiatrists. Current nonsurgical treatment modalities and surgical options for severe symptomatic intervertebral disc degeneration have limited and inconsistent clinical results. Thus, the development of…

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Clinical study of lumbar fusion by hybrid construct of stem cells technique and biodegradable material

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Zhonghua Wai Ke Za Zhi. 2008 Apr 1;46(7):493-6 Authors: Zhang P, Gan YK, Tang J, Hao YQ, Wang Y, Sun YH, Zhu ZA, Dai KR OBJECTIVE: To explorer the effectiveness of enriched bone marrow stem cells technique for lumbar fusion. METHODS: With the randomization and control principles, 2 graft materials [Enrichment bone marrow mesenchymal stem…

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The fate of transplanted xenogeneic bone marrow-derived stem cells in rat intervertebral discs.

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J Orthop Res. 2009 Mar;27(3):374-9 Authors: Wei A, Tao H, Chung SA, Brisby H, Ma DD, Diwan AD Intervertebral disc degeneration is a major cause and a risk factor for chronic low back pain. The potential of using stem cells to treat disc degeneration has been raised. The aims of our study were to assess…

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Stem cell applications in intervertebral disc repair.

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Cell Mol Biol (Noisy-le-grand). 2008;54(1):24-32 Authors: Hiyama A, Mochida J, Sakai D There is increasing rise of interest in stem cell therapy, as it provides new options for treating a broad range of diseases. Several experimental methods are being explored for the use of stem cells in delaying or reversing the degenerative process of the…

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Tissue engineering and the intervertebral disc: the challenges.

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Eur Spine J. 2008 Dec;17 Suppl 4:480-91 Authors: Kandel R, Roberts S, Urban JP Disc degeneration is a common disorder. Although the back pain that can develop in association with this is rarely life-threatening, the annual cost in terms of morbidity, lost productivity, medical expenses and workers’ compensation benefits is significant. Surgical intervention as practised…

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Future perspectives of cell-based therapy for intervertebral disc disease.

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Eur Spine J. 2008 Dec;17 Suppl 4:452-8 Authors: Sakai D. Intervertebral disc degeneration is a primary cause of low back pain and has a high societal cost. Research on cell-based therapies for intervertebral disc disease is emerging, along with the interest in biological therapy to treat disc disease without reducing the mobility of the spinal…

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Transplantation of human mesenchymal stems cells into intervertebral discs in a xenogeneic porcine model.

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Spine (Phila Pa 1976). 2009 Jan 15;34(2):141-8 Authors: Henriksson HB, Svanvik T, Jonsson M, Hagman M, Horn M, Lindahl A, Brisby H STUDY DESIGN: Experimental and descriptive study of a xenotransplantation model in minipigs. OBJECTIVE: To study survival and function of human mesenchymal stem cells (hMSCs) after transplantation into injured porcine spinal discs, as a…

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MSC response to pH levels found in degenerating intervertebral discs.

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Biochem Biophys Res Commun. 2009 Feb 20;379(4):824-9 Authors: Wuertz K, Godburn K, Iatridis JC Painful degenerative disc disease is a major health problem and for successful tissue regeneration, MSCs must endure and thrive in a harsh disc microenvironment that includes matrix acidity as a critical factor. MSCs were isolated from bone marrow of Sprague-Dawley rats…

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An in vitro study investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tissue.

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Arthritis Res Ther. 2009;11(1):R20 Authors: Le Maitre CL, Baird P, Freemont AJ, Hoyland JA INTRODUCTION: The decreased disc height characteristic of intervertebral disc (IVD) degeneration has often been linked to low back pain, and thus regeneration strategies aimed at restoring the disc extracellular matrix and ultimately disc height have been proposed as potential treatments for…

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Expression and role of connective tissue growth factor in painful disc fibrosis and degeneration.

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Spine (Phila Pa 1976). 2009 Mar 1;34(5):E178-82 Authors: Peng B, Chen J, Kuang Z, Li D, Pang X, Zhang X STUDY DESIGN: We collected the specimens of lumbar intervertebral discs from patients with discogenic low back pain, to study the histopathological features and connective tissue growth factor (CTGF) expressions. OBJECTIVE: To study the expression and…

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