Orthopedics Library

Feasibility of a stem cell therapy for intervertebral disc degeneration.

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Spine J. 2008 Nov-Dec;8(6):888-96 Authors: Sobajima S, Vadala G, Shimer A, Kim JS, Gilbertson LG, Kang JD BACKGROUND CONTEXT: Different strategies to supplement/replenish the disc cell population have been proposed. Recently, adult stem cells have shown promise as a cell source for a variety of tissue engineering and cell therapy applications. A stem cell can…

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Transplantation of mesenchymal stem cells in a canine disc degeneration model.

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J Orthop Res. 2008 May;26(5):589-600 Authors: Hiyama A, Mochida J, Iwashina T, Omi H, Watanabe T, Serigano K, Tamura F, Sakai D Transplantation of mesenchymal stem cells (MSCs) is effective in decelerating disc degeneration in small animals; much remains unknown about this new therapy in larger animals or humans. Fas-ligand (FasL), which is only found…

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Adipose stem cells for intervertebral disc regeneration: current status and concepts for the future.

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J Cell Mol Med. 2008 Dec;12(6A):2205-16 Authors: Hoogendoorn RJ, Lu ZF, Kroeze RJ, Bank RA, Wuisman PI, Helder MN New regenerative treatment strategies are being developed for intervertebral disc degeneration of which the implantation of various cell types is promising. All cell types used so far require in vitro expansion prior to clinical use, as…

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Stem cell-mediated regeneration of the intervertebral disc: cellular and molecular challenge.

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Neurosurg Focus. 2008;24(3-4):E21 Authors: Jandial R, Aryan HE, Park J, Taylor WT, Snyder EY Regenerative medicine and stem cells hold great promise for intervertebral disc (IVD) disease. The therapeutic implications of utilizing stem cells to repair degenerated discs and treat back pain are highly anticipated by both the clinical and scientific communities. Although the avascular…

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Coculture of bone marrow mesenchymal stem cells and nucleus pulposus cells modulate gene expression profile without cell fusion.

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Spine (Phila Pa 1976). 2008 Apr 15;33(8):870-6 Authors: Vadalà G, Studer RK, Sowa G, Spiezia F, Iucu C, Denaro V, Gilbertson LG, Kang JD STUDY DESIGN: Changes in gene expression profile and cell fusion of mesenchymal stem cells (MSC) and nucleus pulposus cells (NPC) after coculture were analyzed. OBJECTIVE: To investigate the mechanisms of the…

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Stem cell regeneration of degenerated intervertebral discs: current status.

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Curr Pain Headache Rep. 2008 Apr;12(2):83-8 Authors: Richardson SM, Hoyland JA Low back pain (LBP) is one of the most common musculoskeletal conditions, and intervertebral disc (IVD) degeneration is associated with most cases. Although many treatment options are available, they focus on the removal of symptoms rather than repair of the degenerate tissue. However, there…

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Disc regeneration: a glimpse of the future.

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Clin Neurosurg. 2007;54:122-8 Authors: Tow BP, Hsu WK, Wang JC The normal IVD clinically acts to support and dissipate loads while permitting multiaxial motions of the spine. Its demanding mechanical function is provided by a well-defined microstructural organization and biochemical composition. IVD degeneration is a complex process that disrupts this well-defined organization and biochemical balance.…

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Magnetic resonance imaging of iron oxide labelled stem cells: applications to tissue engineering based regeneration of the intervertebral disc.

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Eur Cell Mater. 2008;16:17-25 Authors: Saldanha KJ, Piper SL, Ainslie KM, Kim HT, Majumdar S Minimally-invasive monitoring of regeneration in diseased tissue is an important aspect of stem cell therapy. Magnetic resonance imaging (MRI) based tracking of cells labelled with ferumoxides has the potential for non-invasive in vivo detection and longitudinal assessment of implanted cells.…

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Adipose-derived mesenchymal stem cells from the sand rat: transforming growth factor beta and 3D co-culture with human disc cells stimulate proteoglycan and collagen type I rich extracellular matrix.

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Arthritis Res Ther. 2008;10(4):R89 Authors: Tapp H, Deepe R, Ingram JA, Kuremsky M, Hanley EN, Gruber HE INTRODUCTION: Adult mesenchymal stem cell therapy has a potential application in the biological treatment of disc degeneration. Our objectives were: to direct adipose-derived mesenchymal stem cells (AD-MSC) from the sand rat to produce a proteoglycan and collagen type…

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Biological treatment for degenerative disc disease: implications for the field of physical medicine and rehabilitation.

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Am J Phys Med Rehabil. 2008 Sep;87(9):694-702 Authors: Zhang Y, An HS, Tannoury C, Thonar EJ, Freedman MK, Anderson DG Spine care is a fast-growing sector of the outpatient practice for physiatrists. Current nonsurgical treatment modalities and surgical options for severe symptomatic intervertebral disc degeneration have limited and inconsistent clinical results. Thus, the development of…

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