• After the Covid pandemic, we have resumed stem cell treatments. Appropriate sterility and great care in sanitisation is undertaken as usual. If you are unwell with a cough cold or respiratory symptoms it is best to postpone your procedure.

Rheumatoid Arthritis Library

Clinical results and second-look arthroscopic findings after treatment with adipose-derived stem cells for knee osteoarthritis

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Knee Surg Sports Traumatol Arthrosc 2015 May;23(5):1308-16.   Clinical results and second-look arthroscopic findings after treatment with adipose-derived stem cells for knee osteoarthritis Yong-Gon Koh 1, Yun-Jin Choi, Sae-Kwang Kwon, Yong-Sang Kim, Jee-Eun Yeo Center for Stem Cell and Arthritis Research, Department of Orthopedic Surgery, Yonsei Sarang Hospital, 478-3, Bangbae-dong, Seocho-gu, Seoul, South Korea.  …

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What comes first? Multitissue involvement leading to radiographic osteoarthritis: magnetic resonance imaging-based trajectory analysis over four years in the osteoarthritis initiative

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Arthritis Rheumatol 2015 May;67(8):2085-96.   What comes first? Multitissue involvement leading to radiographic osteoarthritis: magnetic resonance imaging-based trajectory analysis over four years in the osteoarthritis initiative Frank W Roemer 1, C Kent Kwoh 2, Michael J Hannon 3, David J Hunter 4, Felix Eckstein 5, Tomoko Fujii 3, Robert M Boudreau 3, Ali Guermazi 6 1Boston University School of Medicine, Boston, Massachusetts, and University of Erlangen-Nuremberg, Erlangen, Germany. 2University of…

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Autologous Stromal Vascular Fraction: A New Era of Personal Cell Therapy

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Journal of Stem Cells Research Development & Therapy, 2018, 4: 011 Autologous Stromal Vascular Fraction: A New Era of Personal Cell Therapy Elliot B Lander and Mark H Berman California Stem Cell Treatment Center, Cell Surgical Network Inc., California, USA   ABSTRACT The fascinating story of Stromal Vascular Fraction (SVF) and its prominent role in autologous…

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Regulation of TNFalpha and IL1beta in rheumatoid arthritis synovial fibroblasts by leukotriene B4.

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Rheumatol Int. 2010 Jul;30(9):1183-9 Authors: Xu S, Lu H, Lin J, Chen Z, Jiang D Arachidonic acid metabolites, such as leukotriene B4 (LTB4), are known to play an important role in pathogenesis of rheumatoid arthritis (RA). Apart from leukocytes, RA synovial fibroblasts (RASF) produce a broad array of inflammatory mediators to recruit, retain and activate…

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Monoclonal antibodies: new therapeutic agents for autoimmune hemolytic anemia?

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Endocr Metab Immune Disord Drug Targets. 2008 Mar;8(1):62-8 Authors: D’Arena G, Taylor RP, Cascavilla N, Lindorfer MA Conventional treatment of autoimmune hemolytic anemia (AIHA) comprises corticosteroids and splenectomy and/or other immunosuppressive drugs for refractory/relapsed patients. Monoclonal antibodies (MoAbs) rituximab and alemtuzumab have gained widespread acceptance in the management of B-cell malignancies. More recently, they have…

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Bmx regulates LPS-induced IL-6 and VEGF production via mRNA stability in rheumatoid synovial fibroblasts.

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Biochem Biophys Res Commun. 2008 Jun 13;370(4):599-602 Authors: Palmer CD, Mutch BE, Page TH, Horwood NJ, Foxwell BM Discordant cytokine production is characteristic of chronic inflammatory conditions like rheumatoid arthritis (RA), and anti-cytokine therapeutics are becoming routinely used to treat RA in the clinic. Fibroblasts from rheumatoid synovium have been shown to contribute to cytokine…

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Rheumatoid arthritis and cardiovascular disease.

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Curr Atheroscler Rep. 2008 Apr;10(2):128-33 Authors: Dhawan SS, Quyyumi AA Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease affecting approximately 1% of the adult general population. Cardiovascular disease is recognized as the leading cause of death in RA patients, accounting for nearly 40% of their mortality. Patients with RA are at a twofold increased…

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Tumor necrosis factor-alpha inhibits chondrogenic differentiation of synovial fibroblasts through p38 mitogen activating protein kinase pathways.

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Mod Rheumatol. 2008;18(4):366-78 Authors: Okuma-Yoshioka C, Seto H, Kadono Y, Hikita A, Oshima Y, Kurosawa H, Nakamura K, Tanaka S We previously reported that synovial fibroblast-like cells (SFs) can be differentiated into chondrocytes through activin receptor-like kinase (ALK) 3 activation. The aim of this study was to clarify the effect and signaling pathways of tumor…

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Multipotent mesenchymal stromal cells in articular diseases.

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Best Pract Res Clin Rheumatol. 2008 Apr;22(2):269-84 Authors: Jorgensen C, Djouad F, Bouffi C, Mrugala D, Noël D Although cartilage defects are common features of osteoarthritis and rheumatoid arthritis, current treatments can rarely restore the full function of native cartilage. Recent studies have provided new perspectives for cartilage engineering using multipotent mesenchymal stromal cells (MSC).…

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Evaluation of COX-1/COX-2 selectivity and potency of a new class of COX-2 inhibitors.

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Eur J Pharmacol. 2008 Jun 24;588(1):93-8 Authors: Gierse J, Nickols M, Leahy K, Warner J, Zhang Y, Cortes-Burgos L, Carter J, Seibert K, Masferrer J A new class of selective cyclooxygenase-2 (COX-2) inhibitors has been identified by high throughput screening. Structurally distinct from previously described selective COX-2 inhibitors, these benzopyrans contain a carboxylic acid function…

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